Allison Doyle Brackley, PhD

Born and raised in Texas, I reside in the Texas hill country with my husband and our dogs (a great dane, mastiff rescue, beloved mutt). Prior degrees I've obtained include two Bachelor of Science degrees, Biochemistry and Nutrition, and a Minor in General Science from Texas Woman's University in December 2010. Shortly after college, I enrolled in the Integrated Multidisciplinary Graduate Program in the Graduate School of Biomedical Sciences at the University of Texas Health Science Center at San Antonio (UT Health). My dissertation research was conducted in the lab of Nathaniel A. Jeske, PhD in Oral & Maxillofacial Surgery. March 30, 2017, I successfully defended my dissertation titled Awakening A DORmant Receptor. In May 2017, I received my PhD in Pharmacology as part of UT Health's Neuroscience Program.

 

Although my dissertation research was focused on the analgesic role of opioid receptors, my postdoctoral fellowship with Glenn M. Toney, PhD in Cellular & Integrative Physiology is focused on methods and mechanisms that counter opioid overdose. 

Patents: 50% Co-discoverer to "Compositions and methods for preventing, reducing and reversing opioid-induced respiratory depression"

Allison Brackley, Glenn Toney, University of Texas System

- U.S. Provisional Patent Application No. 62/914,025

- International Patent Application No. PCT/US2020/054759

UPCOMING & RECENT EVENTS 

Experimental Biology 2021
APS/ASPET
April 26-30, 2021
Virtual Conference
*2021 Research Recognition Award
**2021 American Physiological Society's Data NCARnation Award Session
***Top 12 invited to compete in oral presentations
1. Neural Control and Autonomic Regulation
Activation of Oxytocin Receptor and Oxytocin Neurons of the Hypothalamic Paraventricular Nucleus Are Individually Capable of Reversing Opioid Overdose
2. Central Nervous System
Oxytocin Receptor Activation: An Alternative to Naloxone for Rescuing Opioid-induced Respiratory Depression by Systemic Fentanyl
Experimental Biology 2020
APS
April 4-7, 2020
San Diego, CA
Virtual Conference
Neural Control and Autonomic Regulation
An Alternative to Naloxone for Rescuing Opioid-Induced Respiratory Depression by Systemic Fentanyl in Opioid-Naïve Rats
3rd Biennial Texas Pain Research Consortium Meeting
September 12-13, 2019
San Antonio, TX 
Sheraton Gunther Hotel
A novel rat model of sleep apnea reveals increased hypersensitivity to opioid-induced respiratory depression and reveals tonic suppression of inspiratory drive by endogenous opioids
Experimental Biology 2019
APS/ASPET
April 6-10, 2019
Orlando, FL
2019 Invited to participate in the 2019 American Physiological Society's Data NCARnation Award Session
*Top 12 invited to compete in oral presentations
Neural Control and Autonomic Regulation Section of the American Physiological Society
  1. Endogenous Opioid Tone in the Hypothalamic Paraventricular Nucleus in an Animal Model of Sleep Apnea: Possible Role in Enhanced Sensitivity to Opioid-Induced Respiratory Depression. 
  2. A Novel Rat Model of Sleep Apnea Reveals Increased Sensitivity to Opioid-Induced Respiratory Depression and an Unexpected Role for Endogenous Opioids. 
 
Experimental Biology 2018
APS/ASPET
April 21-25, 2018
San Diego, CA
2018 Research Recognition Award
Central Nervous System Section of the American Physiological Society
Noradrenergic Enhancement of Glutamatergic Synaptic Frequency Among NTS Projecting PVN Neurons: Involvement of a Retrograde Messenger?
Invited Speaker
UT Health
Department of Cellular and Integrative Physiology Symposium
Does the paraventricular nucleus play a role in increased susceptibility to opioid-induced respiratory depression in sleep apnea?
April 20, 2018
 9 AM-5PM
Invited Panelist
Texas A&M San Antonio
Fall Learning Event
The Opioid Epidemic: A Dangerous Prescription for the Workplace
October 17, 2017
6-8 PM
Invited Speaker
Health and Human Services Commission
Prescription Drug Misuse Prevention Town Hall
Tuesday, July 18, 2017
2-5 PM
Oblate Whitley Theological Center
285 Oblate Drive
San Antonio, Texas 78216
NIH Invited & Sponsored Poster Presenter
12th Annual Symposium on
Advances in Pain Research
NIH Campus
Bethesda, MD
May 31-June 1, 2017